The interictal activities load and cognitive performance of children with typical absence epilepsy

Abstract Background The description of childhood absence epilepsy (CAE) a benign self-limited generalized has become matter debate. objectives this work were to evaluate the existence psychiatric and cognitive impairments among patients with typical CAE correlate their possible relation seizure frequency, duration epilepsy, IISL, valproate therapy. Methods study was conducted on 19 receiving therapy, 11 newly diagnosed not AEDs, 30 healthy control subjects (HCS). Participants subjected medical history taking, EEG monitoring, child behavior checklist (CBCL), Stanford Binet Intelligence Scale 5th edition, computerized psychometric tests that assess domains executive functions. Results revealed high rate dysfunctions in patients. 53.3% had problems versus 16.6% HCS. Attention deficit hyperactive disorder (ADHD) (26.6%), anxiety (16.6%), depression (6.6%) most common disorders patient group. Withdrawn/depressed symptoms, thought problems, social attention significantly increased compared At same time, perform worse scales than HCS comparable intelligent quotient (IQ) scores. Conclusion Cognitive appear multifactorial origin epilepsy-related factors including interictal spike load (IISL).